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See the summary below and attached scientific study:
The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Finally, we show that the sera from convalescent SARS patients cross-neutralized SARS-2- S-driven entry. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and ide
This seems promising. Camostat mesylate, a serine protease inhibitor, partially blocked CoV-2 entry into human cells, and even better when combined with E-64d, a protease inhibitor. Camostat is approved in Japan and "could be considered for off-label use." #COVIDー19 #coronavirus https://t.co/sW3coby6Yy
- David Sinclair, PhD AO (@davidasinclair) March 16, 2020
SCIENTIFIC STUDY is located here. PLEASE READ.
Hi Folks, this is huge! Harvard professors are catching on finally that restricting the protease to the ACE2 receptor will inhibit the attack of Unnamed Pandemic. #chaga_gangsta
Self-Quarantine - Don't get bored, stay proactive, learn a new skill.
Coronavirus Live Stats here!
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